110199-16-1Relevant articles and documents
Total Syntheses of Disorazoles A1 and B1 and Full Structural Elucidation of Disorazole B1
Nicolaou,Bellavance, Gabriel,Buchman, Marek,Pulukuri, Kiran Kumar
, p. 15636 - 15639 (2017)
Described herein are the first total syntheses of naturally occurring antitumor agents disorazoles A1 and B1 and the full structural assignment of the latter. The syntheses were achieved through convergent strategies employing enantioselective constructions of the required building blocks, including a novel Sharpless epoxidation/enzymatic kinetic resolution of stannane-containing substrates that led selectively to both enantiomeric forms of an epoxy vinyl stannane, and a series of coupling reactions, including a Wittig reaction, a Suzuki coupling, a Stille coupling, a Yamaguchi esterification and a Yamaguchi macrolactonization.
Total Enantioselective Synthesis of the Endophytic Fungal Polyketide Phomolide H and Its Structural Revision
McNulty, James,McLeod, David
, p. 29 - 33 (2017/01/14)
A total synthesis of the proposed structure of the natural polyketide-macrolactone phomolide H 2 has been achieved following a bidirectional strategy from l-tartaric acid. The originally assigned structure of phomolide H displayed discordant NMR spectroscopic data in comparison with synthetic 2. The synthetic strategy was extended to prepare diastereomers and epimeric methyl-ethers of the natural product, structural analysis of which revealed a match of the natural product with diastereomer 27. The structural revision of phomolide H from 2 to the methanol solvate of compound 27 is presented.
Liquid Chromatographic Resolution of Racemic 2-Oxazolidinones and their Analogs on Seven Pirkle-Type Chiral Stationary Phases
Yu, Jeong Jae,Hyun, Myung Ho,Armstrong, Daniel W.,Breitbach, Zachary S.,Ryoo, Jae Jeong
, p. 723 - 726 (2015/07/20)
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