916771-62-5

Upstream product

• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 
• 177606-51-8 2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 913253-38-0 2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl methanesulfonate 
• 916771-73-8 tert-butyl-(2-chloromethyl-allyloxy)-diphenyl-silane 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 916771-63-6 3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-hex-5-enoyl]-4-phenyl-oxazolidin-2-one 
• 916771-77-2 9-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-7-methyl-5-triethylsilanyloxy-dec-9-enoic acid 2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 916771-76-1 7-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-3-triethylsilanyloxy-oct-7-enoic acid 2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 916771-75-0 7-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-5-methyl-oct-7-enoic acid 2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 916771-89-6 7-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-3-triethylsilanyloxy-oct-7-en-1-ol 
• 916771-81-8 4-{6-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-pent-4-enyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester 
• 916771-64-7 7-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-3-triethylsilanyloxy-oct-7-enal 
• 916771-78-3 9-(tert-butyl-diphenyl-silanyloxymethyl)-3,5-dihydroxy-7-methyl-dec-9-enoic acid 
• 916771-65-8 6-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-pent-4-enyl]-4-hydroxy-tetrahydro-pyran-2-one 
• 916771-66-9 {6-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-pent-4-enyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde 
• 916771-80-7 tert-butyl-{2-[3-(6-ethoxy-3,6-dihydro-2H-pyran-2-yl)-2-methyl-propyl]-allyloxy}-diphenyl-silane 
• 916771-79-4 6-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-pent-4-enyl]-5,6-dihydro-pyran-2-one 
• 916771-74-9 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-hex-5-enal 

Relevant academic research and scientific papers

Preparation of 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives by cobalt catalyzed sp2-sp3 coupling

A practical, operationally simple preparation of 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives is described. The cobalt catalyzed coupling of a protected vinyl halide with trimethylsilylmethylmagnesium chloride shows excellent functional group tolerance and provides these synthetically useful allyl silanes in good overall yield. By this method, the use of highly concentrated organolithium reagents, complex reaction protocols, and expensive starting materials is avoided.

Synthetic studies on a phenyl-laulimalide analogue

An analogue of the paclitaxel-like antimicrotubule agent laulimalide with a phenyl in place of the dihydropyran has been synthesized. The fragments C1-C14 and C15-C28 were coupled via a stereoselective intermole