916830-71-2

Upstream product

• 916830-69-8 (S)-4-(2-trifluoromethylphenyl)pyrrolidin-2-one 

Downstream Products

• 1032199-10-2 (S)-3-(2-trifluoromethylphenyl)pyrrolidine (+)-10-camphorsulfonate 
• 916830-79-0 (S)-3-(2-trifluoromethylphenyl)pyrrolidine hydrochloride 
• 1346551-90-3 (S)-(6-(piperidin-1-yl)pyridin-2-yl)(3-(2-(trifluoromethyl)phenyl)pyrrolidine-1-yl)methanone 
• 1346555-15-4 (S)-(6-bromopyridin-2-yl)(3-(2-(trifluoromethyl)phenyl)pyrrolidin-1-yl)methanone 

Relevant academic research and scientific papers

METHOD FOR PRODUCING PYRROLIDINE COMPOUND

Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. A method of producing a compound represented by the following formula [8]: or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: or a reactive derivative thereof, or a salt thereof, or a solvate thereof.

Heterocyclic compounds

The present invention provides a compound represented by the following formula [1′] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a