916850-58-3Relevant academic research and scientific papers
Studies towards complex bridged alkaloids: regio- and stereocontrolled enolate chemistry of 2,5-diketopiperazines
Pichowicz, Mark,Simpkins, Nigel S.,Blake, Alexander J.,Wilson, Claire
, p. 3713 - 3735 (2008/09/21)
The substitution of symmetrical N-protected diketopiperazines (DKPs) via enolate intermediates has been studied. The enolate reactions were highly diastereocontrolled, leading to enantiopure DKP products if chiral amino acid precursors were employed, and
Synthesis towards complex bridged alkaloids derived from diketopiperazines: a cationic cascade approach to stephacidins, paraherquamides and related systems
Pichowicz, Mark,Simpkins, Nigel S.,Blake, Alexander J.,Wilson, Claire
, p. 8413 - 8417 (2007/10/03)
Regioselective enolate formation, followed by stereoselective electrophilic quenching of unsymmetrical proline-derived diketopiperazines (DKPs), enabled the synthesis of variously substituted DKPs, including one substrate which could be further substitute
