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Upstream product

• 7338-80-9 6-(phenylmethyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 81118-79-8 phenyl pyruvic acid thiosemicarbazone 
• 100-52-7 benzaldehyde 
• 90946-40-0 6-benzyl-2H-[1,2,4]triazine-3,5-dione 

Relevant academic research and scientific papers

Synthetic approach to 6-benzoyl-2H-[1,2,4] triazine-3,5-dione and 6-benzyl-5-thioxo-3,4-dihydro-2H-[1,2,4] triazin-3-one and studies on their transformation to fused [1,2,4]triazine systems

Reaction of phenylpyruvic acid with semicarbazide afforded 6-benzyl-2H-[1,2,4]triazine-3,5-dione (1) which upon oxidation with potassium dichromate furnished 6-benzoyl-2H-[1,2,4]triazine-3,5-dione (2) in good yield. Constructing pyrazolo[3,4-e][1,2,4] triazine system (4) was achieved by reacting 2 with arylhydrazines in ethanolic solution. However treatment of 2 with the less reactive heteroarylhydrazines gave only the corresponding hydrazones (3). Attempt for constructing 1,2,4,5,10-pentaaza-dibenzo[a,d]cyclohept-3-one (7) from 2 was failed and (benzoimidazol-2-yl) [1,2,4] triazine derivative (6) was the only product. Reaction of 1 with phosphorus pentasulphide afforded compounds 8 and 9. Compound 8 was transformed to the hydrazino compound 14, which led to the construction of triazolo[4,3-d] [1,2,4]triazine system. Thus compounds 15 and 16 were obtained by reacting 14 with carbon disulfide or acetic anhydride respectively. Attempt to couple 8 with chloroacetic acid failed, while it's known isomer 10 led to the formation of thiazolo [2,3-c] [1,2,4]triazine derivative (13). Simple theoretical calculation using AM1 and PM3 semiempirical Hamitonian provided rational ways to correlate the reactivity with structure proposed.

Synthesis and Antimicrobial Activity of 6-Benzyl/p-substituted-benzyl-1,2,4-triazine-3,5-(2H,4H)-dithione

6-Benzyl-1,2,4-triazine-3,5-(2H,4H)-dithione (IIa) and its p-substituted benzyl derivatives (IIb-d) have been prepared from benzaldehyde and substituted benzaldehydes respectively.The compounds have been characterised on the basis of spectral data (UV, IR, PMR and mass) and have also been tested for their antimicrobial activity against a number of bacteria.