916907-01-2Relevant academic research and scientific papers
Synthesis of novel pyrimido[4,5-c]pyridazines and 1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-ones as potent inhibitors of lymphocyte specific kinase (LCK)
VanRens, John C.,Sabat, Mark,Brugel, Todd A.,Maier, Jennifer,Laufersweiler, Matthew J.,Golebiowski, Adam,Berberich, Steve,De, Biswanath
, p. 2037 - 2044 (2008/01/27)
This paper details the synthesis of a novel class of 1,2-dihydro-pyrimido[4,5-c]pyridazines and substituted 1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-one. The most potent analogs disclosed showed low nanomolar activity for the inhibition of
