916978-58-0

Basic information

• Product Name: 2-bromo-6-nitrophenylacetylene diethylphosphonate
• Synonyms: 2-bromo-6-nitrophenylacetylene diethylphosphonate
• CAS NO: 916978-58-0
• Molecular Weight: 362.117
• Mol File: 916978-58-0.mol

Chemical Properties

• CAS DataBase Reference: 2-bromo-6-nitrophenylacetylene diethylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-6-nitrophenylacetylene diethylphosphonate(916978-58-0)
• EPA Substance Registry System: 2-bromo-6-nitrophenylacetylene diethylphosphonate(916978-58-0)

Safety Data

• Hazardous Substances Data: 916978-58-0(Hazardous Substances Data)

Upstream product

• 916978-57-9 6-bromo-2-nitrophenylacetylene 
• 814-49-3 diethyl chlorophosphate 
• 20357-21-5 2-bromo-6-nitrobenzaldehyde 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 105205-47-8 [(E)-2-(2-Bromo-6-nitro-phenyl)-vinyl]-dimethyl-amine 

Relevant articles and documents

Diels-Alder approach to polysubstituted biaryls: Rapid entry to tri- and tetra-ortho-substituted phosphorus-containing biaryls

Rapid construction: A Diels-Alder-based approach to the synthesis of highly functionalized biaryls from readily available precursors is disclosed. The utility of these biaryl templates in palladium-mediated couplings is explored along with subsequent redu

METHOD FOR MAKING BIARYL COMPOUNDS, COMPOUNDS MADE BY THE METHOD, AND METHOD FOR THEIR USE

Certain disclosed embodiments of the present invention concern a method for making biaryl compounds by combining a diene with a dienophile under reaction conditions that facilitate a Diels-Alder reaction. Certain embodiments are particularly directed to making a tetra-ortho-substituted biaryl compounds. The disclosed method may involve using novel dienes, dienophiles, or both. Similarly, certain of the biaryl compounds are novel compounds too. Additional disclosed embodiments concern a method for making useful compounds by first making a Diels-Alder adduct. The Diels-Alder adduct is then further modified or coupled to other compounds. The method can be used to make carbazoles, such as Siamenol. Disclosed biaryl compounds are useful for a number of applications, such as pharmacophores and organocatalysts.

Synthesis of tetra-ortho-substituted, phosphorus-containing and carbonyl-containing biaryls utilizing a Diels-Alder approach

The application of the Diels-Alder approach to biaryls (DAB) is described for the synthesis of tetra-ortho-substituted biaryl compounds containing orthogonally functionalized substituents. The syntheses of phosphorus- containing, disubstituted alkynes and