917237-11-7Relevant academic research and scientific papers
Collective Syntheses of 2-(3-Methylbenzofuran-2-yl)phenol-Derived Natural Products by a Cascade [3,3]-Sigmatropic Rearrangement/Aromatization Strategy
Tang, Yingzhan,Jiang, Chongguo,Zhang, Xinhang,Liu, Chengjun,Lin, Jingsheng,Wang, Yanshi,Du, Chuan,Peng, Xiaoshi,Li, Wei,Liu, Yongxiang,Cheng, Maosheng
, p. 11102 - 11109 (2017/10/27)
A cascade [3,3]-sigmatropic rearrangement/aromatization strategy to the synthesis of 2-(3-methylbenzofuran-2-yl)phenol derivatives was developed and applied to the collective syntheses of seven 2-arylbenzofuran-containing natural products, namely glycybenzofuran, glycyuralin E, lespedezol A1, puerariafuran, 7,2′,4′-trihydroxy-3-benzofurancarboxylic acid, coumestrol, and 4′-O-methylcoumestrol. Among them, the total syntheses of glycybenzofuran, glycyuralin E, puerariafuran, 7,2′,4′-trihydroxy-3-benzofurancarboxylic acid, and 4′-O-methylcoumestrol were reported for the first time. The practicality of this novel strategy in preparation of the key intermediates was demonstrated by performing the reaction on gram scale and by synthesizing a series of natural products with 2-(3-methylbenzofuran-2-yl)phenol scaffolds in a common strategy.
A PROCESS FOR THE PREPARATION PUERARIAFURAN
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Paragraph 0042; 0189-0193, (2016/12/22)
The present invention relates to a chemical method for producing puerariafuran, which is separated from Pueraria thunbergiana having various physiological activities, and derivatives thereof. The chemical method for producing puerariafuran and derivatives
First synthesis and anti-inflammatory effects of puerariafuran and its derivatives
Yoon, Hyun-Ho,Kim, Jin-Kyung,Jun, Jong-Gab
, p. 571 - 577 (2015/05/05)
The total synthesis of puerariafuran and its derivatives was achieved for the first time by the direct reaction between substituted α-bromoacetophenones and resorcinol. The reaction was mediated by neutral alumina and was fully regio-controlled. Subsequen
