98314-70-6

Basic information

• Product Name: 2-(2-acetyl-5-(benzyloxy) phenoxy)acetic acid ethyl ester
• Synonyms: 2-(2-acetyl-5-(benzyloxy) phenoxy)acetic acid ethyl ester
• CAS NO: 98314-70-6
• Molecular Weight: 328.365
• Mol File: 98314-70-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-acetyl-5-(benzyloxy) phenoxy)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-acetyl-5-(benzyloxy) phenoxy)acetic acid ethyl ester(98314-70-6)
• EPA Substance Registry System: 2-(2-acetyl-5-(benzyloxy) phenoxy)acetic acid ethyl ester(98314-70-6)

Safety Data

• Hazardous Substances Data: 98314-70-6(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 100-39-0 benzyl bromide 
• 105-39-5 chloroacetic acid ethyl ester 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 98314-71-7 2-ethoxycarbonylmethoxy-4-hydroxyacetophenone 
• 479-13-0 coumestrol 
• 796089-78-6 coumestrol 
• 917237-11-7 3-formyl-2-(4-hydroxy-2-methoxyphenyl)-6-hydroxybenzofuran 
• 1253641-15-4 2-[4,6-dihydroxy-3-(γ,γ-dimethylallyl)-2-methoxyphenyl]-6-hydroxy-3-methyl-benzofuran 
• 73640-77-4 6-benzyloxy-3-methyl-benzofuran 
• 98314-79-5 (E)-4-{3-Methoxycarbonylmethoxy-4-[3-(4-methoxycarbonylmethoxy-phenyl)-propionyl]-phenoxy}-2-methyl-but-2-enoic acid methyl ester 

Relevant articles and documents

Identification of 10-dehydrooxyglycyuralin E as a selective human estrogen receptor alpha partial agonist

Selective estrogen receptor modulators (SERMs)act as either agonist or antagonist of estrogen receptor (ER)in a tissue selective manner and have been used in several diseases such as breast cancer, postmenopausal syndrome, osteoporosis, and cardiovascular diseases. However, current SERMs may also increase the risk of serious side effects and trigger drug resistance. Herein, a screening program, that was designed to search for novel SERMs, resulted in the identification of a series of 2-arylbenzofuran-containing compounds that are ligands for ERα, when applying the Gaussia-luciferase reporter assay. One of these compounds, 10-dehydrooxyglycyuralin E (T9)was chemically synthesized. T9 showed anti-estrogenic/proliferative activity in ERα-positive breast cancer cells. Pretreatment of T9 prevented the mRNA expression of GREB1, which is an estrogen response gene. Furthermore, by an in silico docking simulation study we demonstrated that T9 showed interactions directly to ERα. Taken together, these results demonstrated that T9 is a candidate of SERMs and a useful seed compound for the foundation of the selective activity of SERMs.

Anti-ulcer effect of isoprenyl flavonoids. III. Synthesis and anti-ulcer activity of metabolites of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy)chalcone

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