917239-33-9Relevant academic research and scientific papers
S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
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, (2021/06/22)
Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.
Synthesis and anti-HIV activity of β-D-3′-azido-2′, 3′-unsaturated nucleosides and β-D-3′-azido-3′- deoxyribofuranosylnucleosides
Gadthula, Srinivas,Chu, Chung K.,Schinazi, Raymond F.
, p. 1707 - 1727 (2007/10/03)
□ Since the discovery of 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-didehydro-2prime;,3′-dideoxythymidine (d4T) as potent and selective inhibitors of the replication of human immunodeficiency virus (HIV), there has been a growing interest for the synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides with electron withdrawing groups on the sugar moiety. Here we described an efficient method for the synthesis of such nucleoside analogs bearing structural features of both AZT and d4T. The hey intermediate, 3-azido-1,2-bis-O-acetyl-5-O-benzoyl-3- deoxy-D-ribofuranose, 5 was synthesized from commercially available D-xylose in five steps, from which a series of pyrimidine and purine nucleosides were synthesized in high yields. The resultant protected nucleosides were converted to target nucleosides using appropriate chemical modifications. The final nucleosides were evaluated as potential anti-HIV agents. Copyright Taylor & Francis Group, LLC.
