91732-92-2

Upstream product

• 82241-27-8 5-(4-chlorobenzoyl)aminoorotic acid 

Downstream Products

• 1105521-27-4 C₅H₅N*C₁₂H₆ClN₃O₄ 
• 1105521-22-9 5-(4-chlorobenzoyl)amino-2,6-dihydroxy-N-(4-trifluoromethylphenyl)-4-pyrimidinecarboxamide 
• 1105521-28-5 2-(4-chlorophenyl)-6,8-dichloropyrimido[5,4-d]-4H-1,3-oxazin-4-one 
• 82241-30-3 C₁₄H₁₂ClN₃O₅ 
• 1105521-25-2 5-(4-chlorobenzoyl)amino-N-(1-adamantyl)-2,6-dihydroxy-4-pyrimidinecarboxamide 
• 1105521-24-1 5-(4-chlorobenzoyl)amino-2,6-dihydroxy-N-(4-hydroxycyclohexyl)-4-pyrimidinecarboxamide 

Relevant academic research and scientific papers

New amides of 5-(4-chlorobenzoyl)aminoorotic acid: Their synthesis and biological activity

The synthesis and in-vitro biological evaluation of the amide series 4 of 5-(4-chlorobenzoyl)aminoorotic acid 2 are presented. The biological properties of a few 5-(4-chlorobenzoyl)amino-2,6-dihydroxy-N-substituted-4- pyrimidinecarboxamide derivatives 4 tested here were compared with those of the isosteric isothiazole derivative MR-2/94 (5-(4-chlorobenzoyl)amino-N-(4- chlorophenyl)-3-methyl-4-isothiazolecarboxamide), which possesses a strong immunosuppressive and anti-inflammatory activity [1, 2], It must be suggested that replacement of the isothiazole by a pyrimidine core ring system resulted in considerable lowering of the anti-inflammatory and immunotropic actions of the obtained amides. Physicochemical properties of 2-(4-chlorophenyl)-6,8-dihydroxy- 4H-pyrimido[5,4-d]-1,3-oxazin-4-on 3 are also briefly described.