82241-27-8

Basic information

• Product Name: 4-Pyrimidinecarboxylic acid, 5-[(4-chlorobenzoyl)amino]-1,2,3,6-tetrahydro-2,6-dioxo-
• CAS NO: 82241-27-8
• Molecular Formula: C12H8ClN3O5
• Molecular Weight: 309.666
• Mol File: 82241-27-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Pyrimidinecarboxylic acid, 5-[(4-chlorobenzoyl)amino]-1,2,3,6-tetrahydro-2,6-dioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinecarboxylic acid, 5-[(4-chlorobenzoyl)amino]-1,2,3,6-tetrahydro-2,6-dioxo-(82241-27-8)
• EPA Substance Registry System: 4-Pyrimidinecarboxylic acid, 5-[(4-chlorobenzoyl)amino]-1,2,3,6-tetrahydro-2,6-dioxo-(82241-27-8)

Safety Data

• Hazardous Substances Data: 82241-27-8(Hazardous Substances Data)

Upstream product

• 7164-43-4 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 91732-92-2 C₁₂H₆ClN₃O₄ 

Relevant articles and documents

New amides of 5-(4-chlorobenzoyl)aminoorotic acid: Their synthesis and biological activity

The synthesis and in-vitro biological evaluation of the amide series 4 of 5-(4-chlorobenzoyl)aminoorotic acid 2 are presented. The biological properties of a few 5-(4-chlorobenzoyl)amino-2,6-dihydroxy-N-substituted-4- pyrimidinecarboxamide derivatives 4 tested here were compared with those of the isosteric isothiazole derivative MR-2/94 (5-(4-chlorobenzoyl)amino-N-(4- chlorophenyl)-3-methyl-4-isothiazolecarboxamide), which possesses a strong immunosuppressive and anti-inflammatory activity [1, 2], It must be suggested that replacement of the isothiazole by a pyrimidine core ring system resulted in considerable lowering of the anti-inflammatory and immunotropic actions of the obtained amides. Physicochemical properties of 2-(4-chlorophenyl)-6,8-dihydroxy- 4H-pyrimido[5,4-d]-1,3-oxazin-4-on 3 are also briefly described.