917388-31-9

Upstream product

• 108-24-7 acetic anhydride 
• 158296-69-6 4-amino-3-chloro-5-methylbenzonitrile 
• 75-36-5 acetyl chloride 

Downstream Products

• 917386-10-8 N-(amino(4-amino-3,5-dichlorobenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide 
• 917387-67-8 N-(amino(4-(2-(azetidin-1-yl)acetamido)-3-chloro-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide 
• 917387-89-4 N-(amino(3-chloro-4-(2-(ethylamino)acetamido)-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide 
• 917387-70-3 N-(amino(4-(2-(benzylamino)acetamido)-3,5-dichlorobenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide 
• 917387-83-8 N-(amino(3-chloro-4-(2-(dimethylamino)acetamido)-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide 
• 917388-91-1 N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide 
• 771583-64-3 4-(aminomethyl)-2-chloro-6-methylaniline 
• 1402164-73-1 tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate 
• 1031417-56-7 7-chloro-1H-indazole-5-carbonitrile 

Relevant academic research and scientific papers

SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating mammals suffering from the condition of being overweight.

Indole acetic acid acyl guanidines as beta-secretase inhibitors

There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and

Aminoacetamide acyl guanidines as beta-secretase inhibitors

There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.