917388-58-0

Basic information

• Product Name: 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl e
• Synonyms: 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl e;4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl ester;5-(4-Bromophenyl)-3-methyl-4-isoxazolecarboxylic acid ethyl ester;ETHYL 5-(4-BROMOPHENYL)-3-METHYLISOXAZOLE-4-CARBOXYLATE
• CAS NO: 917388-58-0
• Molecular Formula: C₁₃H₁₂BrNO₃
• Molecular Weight: 310.14328
• Mol File: 917388-58-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl e(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl e(917388-58-0)
• EPA Substance Registry System: 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl e(917388-58-0)

Safety Data

• Hazardous Substances Data: 917388-58-0(Hazardous Substances Data)

Usage

General Description

4-Isoxazolecarboxylic acid, 5-(4-bromophenyl)-3-methyl-, ethyl ester is a chemical compound that belongs to the isoxazolecarboxylic acid derivative class. It is a yellow solid that is commonly used in the field of organic synthesis. 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, ethyl e has potential pharmacological characteristics and is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds. It is important to handle this chemical with caution as it may be harmful if ingested or inhaled, and proper safety protocols should be followed when working with it in a laboratory setting.

Upstream product

• 141-97-9 ethyl acetoacetate 
• 586-75-4 4-chlorobenzoyl chloride 
• 893643-73-7 2-(4-bromobenzoyl)-3-carbonylbutyrate ethyl ester 

Downstream Products

• 91182-60-4 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid 
• 1280205-98-2 (5-(4-bromophenyl)-3-methylisoxazole-4-yl)methanol 

Relevant articles and documents

Lysophosphatidic acid receptor antagonists and preparation method thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to lysophosphatidic acid receptor antagonists and a preparation method thereof. The applicant surprisinglyfinds that compounds provided by the invention have high LPAR1 antagonistic activity and selectivity, low toxicity, good metabolic stability and good drug development prospect, and can be used for preventing or treating diseases or symptoms related to LPAR1. The applicant also accidentally finds that the IC50 value of part of the compounds can be as low as 300 nM or below and even 50 nM or below.Moreover, the compounds disclosed by the invention have better safety, and the CC50 range of the compounds can reach 200 [mu]M or above. In addition, the compounds of the present invention have goodmetabolic stability in humans, rats, and mice, such excellent inhibitory activity being very desirable for their use as LPAR1 inhibitors in the above diseases or disorders. In addition, the preparation method of the compounds is simple, mild in reaction condition, high in product yield and suitable for industrial production.