917388-79-5Relevant academic research and scientific papers
Acyl guanidine inhibitors of β-secretase (bACE-1): Optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis
Gerritz, Samuel W.,Zhai, Weixu,Shi, Shuhao,Zhu, Shirong,Toyn, Jeremy H.,Meredith, Jere E.,Iben, Lawrence G.,Burton, Catherine R.,Albright, Charles F.,Good, Andrew C.,Cook, Lynda S.,Padmanabha, Ramesh,Lentz, Kimberley A.,Sofia, Michael J.,MacOr, John E.,Thompson, Lorin A.,Tebben, Andrew J.,Muckelbauer, Jodi K.,Camac, Daniel M.,Metzler, William,Poss, Michael A.
, p. 9208 - 9223,16 (2020/10/15)
This report describes the discovery and optimization of a BACE-1 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as part of a 6041-membered solid-phase library. The synthesis of multiple follow-up solid- and
