91741-74-1

Upstream product

• 328-38-1 (R)-leucine 
• 91711-92-1 N-t-Butoxycarbonyl-(R)-prolyl-(S)-leucyl-(S)-valyl-2-<1-(R)-amino-3-cyano-prop-1-yl>-thiazole-4-carbonyl-2-thiazole-4-carboxylic acid ethyl ester 
• 14533-84-7 pentafluorophenyl trifloroacetate 
• 91741-73-0 2-[(R)-1-((R)-2-{(R)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carboxylic acid 
• 91711-91-0 N-t-Butoxycarbonyl-(S)-prolyl-(R)-leucyl-(R)-valyl-2<1-(R)-amino-3-cyano-prop-1-yl>thiazole-4-carboxylic acid ethyl ester 
• 91711-92-1 N-t-Butoxycarbonyl-(S)-prolyl-(R)-leucyl-(R)-valyl-2-<1-(R)-amino-3-cyano-prop-1-yl>thiazole-4-carbonyl-2-thiazole-4-carboxylic acid ethyl ester 
• 91741-73-0 2-[(R)-1-((S)-2-{(R)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carboxylic acid 
• 91711-91-0 N-t-Butoxycarbonyl-(S)-prolyl-(R)-leucyl-(S)-valyl-2<1-(R)-amino-3-cyano-prop-1-yl>thiazole-4-carboxylic acid ethyl ester 
• 91711-92-1 N-t-Butoxycarbonyl-(S)-prolyl-(R)-leucyl-(S)-valyl-2-<1-(R)-amino-3-cyano-prop-1-yl>-thiazole-4-carbonyl-2-thiazole-4-carboxylic acid ethyl ester 
• 91741-73-0 2-[(R)-1-((R)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carboxylic acid 
• 91711-91-0 N-t-Butoxycarbonyl-(S)-prolyl-(S)-leucyl-(R)-valyl-2<1-(R)-amino-3-cyano-prop-1-yl>thiazole-4-carboxylic acid ethyl ester 
• 91711-92-1 N-t-Butoxycarbonyl-(S)-prolyl-(S)-leucyl-(R)-valyl-2-<1-(R)-amino-3-cyano-prop-1-yl>-thiazole-4-carbonyl-2--thiazole-4-carboxylic acid ethylester 
• 91741-73-0 2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carboxylic acid 
• 91711-91-0 N-t-Butoxycarbonyl-(S)-prolyl-(S)-leucyl-(S)-valyl-2<1-(R)-amino-3-cyano-prop-1-yl>thiazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Amino Acids and Peptides; 60. Synthesis of Biologically Active Cyclopeptides; 10. Synthesis of 16 Structural Isomers of Dolastatin 3; II: Synthesis of the Linear Educts and the Cyclopeptides

Sixteen isomers of the cancerostatic cyclopeptide Dolastatin 3 of marine origin are synthesized.The proposed structure of Dolastatin 3 is proved to be not correct.