91741-84-3

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 496-15-1 1-indoline 

Downstream Products

• 91715-41-2 Sodium; [2-amino-5-bromo-3-(4-chloro-benzoyl)-phenyl]-acetate 
• 91714-37-3 5-Bromo-7-(4-chloro-benzoyl)-1,3-dihydro-indol-2-one 
• 91714-65-7 (4-Chloro-phenyl)-(3,5-dibromo-1H-indol-7-yl)-methanone 
• 91714-57-7 (3-Bromo-5-chloro-1H-indol-7-yl)-(4-chloro-phenyl)-methanone 
• 91714-49-7 (3-Chloro-1H-indol-7-yl)-(4-chloro-phenyl)-methanone 
• 91714-64-6 (5-Bromo-1H-indol-7-yl)-(4-chloro-phenyl)-methanone 
• 91714-56-6 (5-Chloro-1H-indol-7-yl)-(4-chloro-phenyl)-methanone 
• 405275-39-0 (4-chloro-phenyl)-(1-ethyl-1H-indol-7-yl)-methanone 
• 91714-46-4 (5-bromo-2,3-dihydro-1H-indol-7-yl)(4-chlorophenyl)methanone 
• 91714-42-0 (5-chloro-2,3-dihydro-1H-indol-7-yl)(4-chlorophenyl)methanone 
• 91714-48-6 (4-chlorophenyl)(1H-indol-7-yl)methanone 

Relevant academic research and scientific papers

Diaryl-substituted (Dihydro)pyrrolo[3,2,1- hi ]indoles, a class of potent COX-2 inhibitors with tricyclic core structure

A new compound class of diaryl-substituted heterocycles with tricyclic dihydropyrrolo[3,2,1-hi]indole and pyrrolo[3,2,1-hi]indole core structures has been designed and was synthesized by a modular sequence of Friedel-Crafts acylation, amide formation, and

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.

Preparation and pharmacological profile of 7-(α-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors

Aromatase (P450 arom) is a target of pharmacological interest for the treatment of breast cancer. New series of 7-(α-azolylbenzyl)-1H-indoles and indolines were synthesized as non-steroidal inhibitors of P450 arom. Selectivity was studied towards P450 17α enzyme. The most active compound, 1-ethyl-7-[(imidazol-1-yl)(4-chlorophenyl)methyl]-1H-indole 12c exhibited promising relative potency (rp) of 336 (rp of aminoglutethimide=1) and most of the described azoles were active and selective towards P450 arom.

Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues

A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 4'-chloro, 4'-bromo and 5-chloro, 4'-bromo were more potent than indomethacin in these assays.