917480-01-4

Upstream product

• 112088-76-3 6-chloro-9-(4-methoxyphenylmethyl)-9H-purine 

Downstream Products

• 917480-02-5 6-(2-furyl)-9-(4-methoxyphenylmethyl)-2-nitro-9H-purine 
• 1246307-27-6 8-bromo-6-chloro-9-[(4-methoxyphenyl)methyl]-2-nitro-9H-purine 
• 1246307-14-1 6,6'-dichloro-9,9'-di[(4-methoxyphenyl)methyl]-2-nitro-9H,9'H-[8,2']bipurinyl 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

A novel method for the introduction of fluorine into the purine 2-position: Synthesis of 2-fluoroadenosine and a formal synthesis of the antileukemic drug fludarabine

A novel method for the introduction of fluorine in the purine 2-position is described and employed in the synthesis of a potential antimycobacterial compound. Also 2-fluoroadenosine has been synthesized for the first time from adenosine with perbenzoylated 2-nitroadenosine as a key intermediate. Mild reaction conditions are employed and few synthetic steps are required. The novel synthesis of fluoroadenosine can be regarded as a formal synthesis of the antileukemic drug fludarabine phosphate. Georg Thieme Verlag Stuttgart.

Purine compounds

The invention provides an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl) purine and purine analog compounds.