917595-31-4Relevant articles and documents
Synthesis and pharmacokinetic and pharmacodynamic evaluation of the forodesine HCl analog BCX-3040
Kezar III, Hollis S.,Kilpatrick, J. Michael,Phillips, Deborah,Kellogg, Debbie,Zhang, Jianwen,Morris Jr., Philip E.
, p. 1817 - 1830 (2005)
□ Forodesine HCl is a potent inhibitor of the enzyme purine nucleoside phosphorylase (PNP) and is currently in clinical trials for the treatment of leukemia and lymphoma. Animal models indicated that forodesine HCl would have low oral bioavailability in h