91780-83-5Relevant academic research and scientific papers
Heterocycles from Nitrile Oxides. II. 1,2,4-Oxadiazin-6-ones
Hussein, Ahmad Q.,El-Abadelah, Mustafa M.,Sabri, Wail S.
, p. 455 - 459 (2007/10/02)
Condensation of arylnitrile oxides with α-amino acid esters, other then those of glycine and alanine, has been found to constitute a synthetic route to the hitherto unknown 1,2,4-oxadiazin-6-ones 7. α-Amino alcohols yield with nitrile oxides the corresponding acyclic N-(arylhydroxamoyl)amino alcohols, which are also accessible by borohydride reduction of compound 7.In contrast, the adducts formed from nitrile oxides and α-amino acids are unstable; they decompose readily into the aldehyde, derived from the amino acid, together with the aldoxime, derived from the nitrile oxide.Both decomposition products are also formed when compounds 7 are subjected to mild hydrolysis.
