917882-64-5

Usage

Uses

Used in Organic Synthesis:
(S)-(1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate is used as a reagent in organic synthesis for the preparation of various chemical compounds. Its unique structure and properties make it a valuable component in the synthesis of complex organic molecules.
Used in Chemical Reactions:
(S)-(1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate is used as a reagent in chemical reactions to facilitate specific transformations or to improve reaction yields. Its presence can enhance the efficiency of certain processes, making it a useful tool in the field of chemistry.
Used in Pharmaceutical Industry:
(S)-(1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate may have applications in the pharmaceutical industry, where it could be used as an intermediate in the synthesis of pharmaceutical compounds or as a reagent in the development of new drugs.
Used in Agrochemical Industry:
(S)-(1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate may also find use in the agrochemical industry, where it could be employed in the synthesis of agrochemicals or as a reagent in the development of new pesticides or herbicides.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 861852-08-6 (2R)-2-[(2-chloroethoxy)methyl]oxirane 
• 861852-07-5 (S)-1-(2-chloroethoxy)-3-chloropropan-2-ol 
• 406913-88-0 (R)-(-)-2-hydroxymethyl-1,4-dioxane 
• 67843-74-7 (S)-epichlorohydrin 
• 107-07-3 2-chloro-ethanol 
• 1170702-79-0 C₄H₇ClO₂ 

Downstream Products

• 917882-66-7 MK-2461 
• 1233483-72-1 benzyl {[[(2R)-1,4-dioxan-2-ylmethyl](methyl)amino]sulfonyl}carbamate 
• 1112169-43-3 6-(2-(((R)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(3-chloro-4-fluoro-benzyl)-2-methyl-pyrimidine-4-carboxamide 
• 1112169-45-5 6-(2-(((R)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(4-fluoro-3-(2-hydroxy-ethoxy)-benzyl)-2-methyl-pyrimidine-4-carboxamide 
• 1112169-41-1 6-(2-(((R)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(4-fluoro-3-methoxybenzyl)-2-methyl-pyrimidine-4-carboxamide 
• 1112169-39-7 6-(2-(((R)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-N-(3-methoxybenzyl)-2-methyl-pyrimidine-4-carboxamide 

Relevant academic research and scientific papers

2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS

Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS

Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION

Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds and methods of using the co

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Process development and large-scale synthesis of a c-Met kinase inhibitor

A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).

Tyrosine kinase inhibitors

This invention relates to salt forms of the compound N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N′-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide, an inhibitor of tyrosine kinases, in particular the receptor tyrosine