917902-99-9

Upstream product

• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 261950-88-3 3-(3-piperidin-1-yl-propoxy)-benzoic acid methyl ester 
• 7781-98-8 ethyl-3-hydroxybenzoate 
• 939772-48-2 C₁₂H₁₅IO₃ 
• 939772-49-3 C₁₇H₂₅NO₃ 
• 117022-45-4 3-(3-chloro-propoxy)-benzoic acid ethyl ester 

Downstream Products

• 917903-00-5 1-[3-(3-pyrrolidin-2-yl-phenoxy)-propyl]-piperidine 
• 945416-28-4 C₂₅H₃₃N₃O₂ 
• 917903-62-9 2-{2-[3-(3-Piperidin-1-yl-Propoxy)-phenyl]-pyrrolidin-1-yl}-1-pyridin-3-yl-ethanone 
• 917903-59-4 2-{2-[3-(3-Piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-1-pyridin-2-yl-ethanone 
• 917903-53-8 2-{2-[3-(3-Piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-1-thiophen-2-yl-ethanone 
• 917903-56-1 2-{2-[3-(3-Piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-1-thiophen-3-yl-ethanone 

Relevant academic research and scientific papers

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors

A series of novel and potent pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. A highly regio- and diastereoselective synthesis of the pyrrolidino-tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.

Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors

A series of novel and potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. In vitro and in vivo data are discussed.

HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS

Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.