939772-49-3Relevant academic research and scientific papers
Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors
Keith, John M.,Gomez, Leslie A.,Wolin, Ronald L.,Barbier, Ann J.,Wilson, Sandy J.,Boggs, Jamin D.,Mazur, Curt,Fraser, Ian C.,Lord, Brian,Aluisio, Leah,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 2603 - 2607 (2008/02/03)
A series of novel and potent pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. A highly regio- and diastereoselective synthesis of the pyrrolidino-tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors
Keith, John M.,Gomez, Leslie A.,Barbier, Ann J.,Wilson, Sandy J.,Boggs, Jamin D.,Lord, Brian,Mazur, Curt,Aluisio, Leah,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 4374 - 4377 (2008/02/11)
A series of novel and potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. In vitro and in vivo data are discussed.
