91795-59-4 Usage
Uses
Used in Neurotransmitter Research:
GLYCINE-2-13C-15N is used as a research tool for studying the role of glycine as an inhibitory neurotransmitter in the spinal cord. The incorporation of stable isotopes allows for improved detection and analysis of glycine's interactions with other neurotransmitters and receptors.
Used in NMDA Receptor Regulation Studies:
GLYCINE-2-13C-15N is utilized as a regulatory agent in research focused on the modulation of NMDA receptors by glycine. The stable isotope labeling enables researchers to better understand the allosteric regulation of these receptors and its implications on neuronal function and synaptic plasticity.
Used in Metabolic Studies:
GLYCINE-2-13C-15N is employed as a tracer in metabolic studies to investigate the role of glycine in various metabolic pathways. The stable isotope labeling allows for the tracking of glycine's metabolism and its contribution to energy production, protein synthesis, and other biological processes.
Used in Pharmaceutical Development:
GLYCINE-2-13C-15N is used as a starting material or intermediate in the synthesis of pharmaceutical compounds targeting the glycine receptor or related pathways. The stable isotope labeling can aid in the development of drugs with improved selectivity, potency, and pharmacokinetic properties.
Used in Diagnostic Imaging:
GLYCINE-2-13C-15N can be used as a contrast agent or tracer in diagnostic imaging techniques, such as magnetic resonance spectroscopy (MRS) or positron emission tomography (PET). The stable isotope labeling enhances the detection and visualization of glycine-related processes in the body, aiding in the diagnosis and monitoring of neurological disorders and other conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 91795-59-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,7,9 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 91795-59:
(7*9)+(6*1)+(5*7)+(4*9)+(3*5)+(2*5)+(1*9)=174
174 % 10 = 4
So 91795-59-4 is a valid CAS Registry Number.
91795-59-4Relevant academic research and scientific papers
Biosynthesis of 5-hydroxy-4-oxo-L-norvaline in Streptomyces akiyoshiensis
White,Smith,DeMarco
, p. 1645 - 1655 (2007/10/02)
The biosynthesis of 5-hydroxy-4-oxo-L-norvaline (HON) in Streptomyces akiyoshiensis has been investigated using 13C-labelled substrates. Incorporations of 13C label from sodium [1-13C]-, [2-13C]-, and [1,2-13C2]acetate indicated that HON was formed from a four-carbon compound derived from the citric acid cycle and the methyl carbon of acetate. Feeding experiments using DL-[4-13C]- and DL-[2-13C,15N]aspartate demonstrated that aspartate served as the four-carbon precursor to HON. Both enantiomers of aspartate were metabolized by S. akiyoshiensis, but the D isomer was consumed at a slower rate. The distribution of 13C label in the intracellular L-glutamic acid isolated in these feeding experiments is consistent with the operation of the citric acid cycle in S. akiyoshiensis. A biosynthetic hypothesis that involves a condensation reaction between acetyl or malonyl CoA and the β-carboxyl group of aspartate, and subsequent oxidative decarboxylation, is proposed to account for the incorporation results. An analogous condensation step has been proposed for the biosynthesis of other natural products, including the carbapenem antibiotics. DL-[2-13C,15N]Aspartate was synthesized from [2-13C]diethylmalonate and potassium [15N]phthalimide via diethyl [2-13C,15N]phthalimidomalonate.
