145143-01-7Relevant academic research and scientific papers
Glycyl Cα chemical shielding in tripeptides: Measurement by solid-state NMR and correlation with X-ray structure and theory
Chekmenev, Eduard Y.,Xu, Ray Z.,Mashuta, Mark S.,Wittebort, Richard J.
, p. 11894 - 11899 (2002)
We report here 13Cα chemical shielding parameters for central Gly residues in tripeptides adopting α-helix, β-strand, polyglycine II, and fully extended 2° structures. To assess experimental uncertainties in the shielding parameters
Synthesis of 13C- and 15N-labelled tert-Butoxycarbonyl (Boc) Glycines and Glycine Amides as Precursors and Simple Models of Backbone-labelled Peptides
Grehn, Leif,Bondesson, Ulf,Pehk, Toenis,Ragnarsson, Ulf
, p. 1332 - 1333 (1992)
Boc-derivatives of the six 13C-labelled glycines with or without 15N have been prepared by a direct approach from the corresponding bromoacetates and three of them converted into 15N-labelled amides by an efficient procedure to give isotopomers with 2-4 adjacent 13C and 15N nuclei; their coupling constants have been recorded.
Synthesis and Spectroscopic Properties of 13C- and 15N-Labelled tert-Butoxycarbonylglycines
Grehn, Leif,Pehk, Toenis,Ragnarsson, Ulf
, p. 1107 - 1111 (2007/10/02)
Three 13C-labelled bromoacetates have been reacted both with 15N-labelled and with unlabelled di-tert-butyl imidodicarbonate and the intermediates selectively deprotected to give the corresponding isotopomeric Boc-glycines for application in peptide synthesis.The products were characterized by 1H, 13C and 15N NMR and FT-IR spectroscopy.Isotope effects on chemical shifts and IR spectra for this set of compounds are tabulated.In addition, from three isotopomers 15N-labelled amides were also prepared.
