917986-04-0Relevant articles and documents
Isobrassinin and its analogues: Novel types of antiproliferative agents
Csomos, Peter,Zupko, Istvan,Rethy, Borbala,Fodor, Lajos,Falkay, George,Bernath, Gabor
, p. 6273 - 6276 (2007/10/03)
Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30 μM). For structure-activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 μM, 76.8%-HeLa and 46.3%-MCF7). The effect of the natural phytoalexin brassinin was also determined.