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1670-84-4

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1670-84-4 Usage

General Description

Indole-2-carboxamide, also known as ICA, is a chemical compound with the molecular formula C9H8N2O. It is a derivative of indole, a bicyclic aromatic compound commonly found in many natural products and pharmaceuticals. Indole-2-carboxamide has been studied for its potential therapeutic applications, particularly in the treatment of neurodegenerative diseases. It has been shown to exhibit neuroprotective and anti-inflammatory properties, making it a potential candidate for the development of new drugs for neurological disorders. Furthermore, indole-2-carboxamide has also been investigated for its antifungal and antimicrobial activities, suggesting its potential use in the development of new antibiotics. Overall, indole-2-carboxamide is a versatile compound with promising potential for various therapeutic and medicinal applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1670-84-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,7 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1670-84:
(6*1)+(5*6)+(4*7)+(3*0)+(2*8)+(1*4)=84
84 % 10 = 4
So 1670-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O/c10-9(12)8-5-6-3-1-2-4-7(6)11-8/h1-5,11H,(H2,10,12)

1670-84-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-Indole-2-carboxamide

1.2 Other means of identification

Product number -
Other names 1H-indole-2-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1670-84-4 SDS

1670-84-4Related news

Pharmacokinetic optimisation of novel Indole-2-carboxamide (cas 1670-84-4) cannabinoid CB1 antagonists09/30/2019

The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB1 antagonist with high predicted human oral bioavailability.detailed

Computer-aided design, synthesis, and biological evaluation of new Indole-2-carboxamide (cas 1670-84-4) derivatives as PI3Kα/EGFR inhibitors09/29/2019

Structure-based drug design and molecular modeling were employed to identify a new series of indole-2-carboxamides as potential anticancer agents. These compounds were synthesized and characterized with the aid of several spectroscopic techniques, such as FT-IR, NMR, and mass spectrometry as wel...detailed

1670-84-4Relevant articles and documents

Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists

Borza, Istvan,Kolok, Sandor,Ignacz-Szendrei, Gyoergyi,Greiner, Istvan,Tarkanyi, Gabor,Galgoczy, Kornel,Horvath, Csilla,Farkas, Sandor,Domany, Gyoergy

, p. 5439 - 5441 (2005)

A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activ

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Leete et al.

, p. 405,407 (1955)

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A new and efficient method for the synthesis of 3-(2-nitrophenyl)pyruvic acid derivatives and indoles based on the Reissert reaction

Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Khikmatova, Gul'naz Z.,Korshin, Dmitry E.,Kushatov, Temur A.,Latypov, Shamil K.

, p. 3923 - 3925 (2018/10/02)

The formation of 3-(2-nitrophenyl)pyruvic acid and its amide and ester derivatives – key compounds for the Reissert indole synthesis – was achieved under various reaction conditions via the acid catalyzed hydrolysis of 5-(2-nitrobenzyliden)-2,2-dimethyl-1,3-oxazolidin-4-one, which is readily available from 3-(2-nitrophenyl)oxirane-2-carboxamide. A new and highly efficient method for the synthesis of indole-2-carboxylic acid derivatives via the intramolecular reductive cyclization of o-nitrophenylpyruvic acid and its amide and ester derivatives was developed using Na2S2O4 in dioxane/water at reflux.

TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

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Page/Page column 48; 49, (2016/05/02)

The present invention is directed to substituted indole compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, adisease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

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