91801-97-7

Usage

InChI:InChI=1/C12H16BrNO/c1-8(15)14-11-6-5-9(7-10(11)13)12(2,3)4/h5-7H,1-4H3,(H,14,15)

Upstream product

• 103273-01-4 2-bromo-4-tert-butylaniline 
• 108-24-7 acetic anhydride 
• 769-92-6 4-tert-Butylaniline 
• 20330-45-4 4-tert-butylacetanilide 

Downstream Products

• 90944-47-1 2-bromo-4-tert-butyl-aniline; hydrochloride 
• 37500-95-1 3,6-di(tert-butyl)-9H-carbazole 
• 1440762-38-8 N,N’-bis(1-ethylpropyl)-2-(4-tert-butylacetanilide-2-yl)perylene-3,4:9,10-tetracarboxylic acid bisimide 
• 3972-64-3 1-bromo-3-(tertbutyl)benzene 
• 388092-72-6 C₇₄H₉₀Si₂ 
• 186772-55-4 C₅₆H₅₀ 
• 388092-70-4 C₄₆H₆₆Si₂ 
• 186772-45-2 1-t-butyl-3-[(triisopropylsilyl)ethynyl]-5-[(trimethylsilyl)ethynyl]benzene 
• 186772-54-3 (3-Bromoethynyl-5-tert-butyl-phenylethynyl)-triisopropyl-silane 
• 186772-49-6 C₂₈H₂₆ 
• 186772-47-4 1-(tert-butyl)-3-ethynyl-5-[(triisopropylsilyl)ethynyl]benzene 
• 191983-33-2 2-bromo-4-tert-butyl-6-iodo-aniline 
• 186772-43-0 1-bromo-3-(tert-butyl)-5-iodobenzene 
• 144001-06-9 1-(trimethylsilyl)-2-(3-bromo-5-tert-butylphenyl)acetylene 

Relevant academic research and scientific papers

Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48percent). This process comprises N -acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

Quinoline synthesis: Scope and regiochemistry of photocyclisation of substituted benzylidenecyclopentanone O-alkyl and O-acetyloximes

Irradiation of substituted 2-benzylidenecyclopentanone O-alkyl and O-acetyloximes in methanol provides a convenient synthesis of alkyl, alkoxy, hydroxy, acetoxy, amino, dimethylamino and benzo substituted annulated quinolines. para-Substituents yield 6-substituted-2,3-dihydro-1H-cyclopenta[b] quinolines with 8-substituted products being obtained from ortho-substituted starting materials. Reactions of meta-substituted precursors are highly regioselective, with alkyl substituents leading to 5-substituted 2,3-dihydro-1H-cyclopenta[b]quinolines and more strongly electron-donating substituents generally resulting in 7-substituted products. 2-Furylmethylene and 2-thienylmethylene analogues yield annulated furo- and thieno-[2,3e]pyridines respectively. Sequential E- to Z-benzylidene group isomerisation and six π-electron cyclisation steps result in formation of a short-lived dihydroquinoline intermediate which spontaneously aromatises by elimination of an alcohol or acetic acid. For 2-benzylidenecyclopentanone O-allyloxime, singlet excited states are involved in both steps. The Royal Society of Chemistry 2007.

Synthesis of butadiyne-bridged [4n] metacyclophanes having exo-annular t-butyl groups

Butadiyne-bridged [44]- and [48]metacyclophanes having exo-annular t-butyl groups were prepared by intermolecular Eglinton coupling of the dimeric unit or by intramolecular ring closure of the linear tetramer. Comparison of the 1H and 13C NMR spectra of [44]metacyclophane with those of [48]cyclophane and diphenylbutadiyne revealed its prominent geometrical feature due to deformation of the triple bonds from linearity. The [44]Metacyclophane was converted into [08]thiophenometacyclophane in good yield by treatment with sodium sulfide.

AROMATIC ACETYLCHOLINESTERASE INHIBITORS

Compounds of general formula (I), stereosiomers and pharmaceutically acceptable salts thereof, wherein each of Z and Z' are independently H or F; Q is (a), CH(OH), (b); X is H, Br, Cl, F or CF3 ; Y is H, Br, Cl, F, OH, OR5, OC(O)R4, N3, CN, NO2, SO3 H, CO

Synthesis and self-association properties of diethynylbenzene macrocycles

We synthesized diethynylbenzene macrocycles (DBMs), cyclic oligomers of diethynylbenzene, having functional groups in the periphery of the macrocyclic framework and investigated their self-association properties in solution resulting from π-π stacking interaction. The tetrakis-DBM having hexadecyl ester groups showed dimerization behavior not only in chloroform-d, but also in o-dichlorobenzene-4.