91815-25-7Relevant articles and documents
NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 44. A NEW GENERAL EFFICIENT SYNTHESIS OF DL--GINGEROLS AND RELATIVES THROUGH DIRECT C-ACYLATION USING DIETHYL PHOSPHOROCYANIDATE (DEPC)
Kato, Nobuharu,Hamada, Yasumasa,Shioiri, Takayuki
, p. 1679 - 1682 (2007/10/02)
DL--Gingerols (1) and their relatives, which have various interesting physiological actions, have been conveniently and efficiently prepared from ferulic acid (2) through direct C-acylation using diethyl phosphorocyanidate (DEPC) in the presence of triethylamine.KEYWORDS - -gingerol; C-acylation; diethyl phosphorocyanidate; β-ketonitrile; Grignard reaction; β-ketol