918307-20-7Relevant academic research and scientific papers
Stereocontrolled synthesis of gem-difluoromethylenated goniodiols and goniothalamin epoxides based on ring-closing metathesis
You, Zheng-Wei,Zhang, Xingang,Qing, Feng-Ling
, p. 2535 - 2542 (2008/02/04)
An efficient and general method to stereoselectively synthesize gem-difluoromethylenated goniodiols and goniothalamin epoxides has been developed. The introduction of a gem-difluoromethyl-containing group was achieved by the reaction of aldehydes with 3-bromo-3,3-difluoropropene in the presence of indium. The gem-difluoromethylenated α,β-unsaturated- δ-lactone moiety was constructed through the ring-closing metathesis of highly electron-deficient gew-difluoromethylenated acryloyl esters by Grubbs' II catalyst in toluene at reflux. Georg Thieme Verlag Stuttgart.
Synthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease
Zaman, Shazia,Campaner, Pietro,Abell, Andrew D.
, p. 8323 - 8331 (2008/02/04)
A versatile synthesis of hydroxylated and epoxy 1-azepin 2-ones substituted at N1, C-3 and C-4 or C-7 has been developed. The sequence involves ring-closing metathesis of an amino acid derived diene amide, followed by either epoxidation or dihydroxylation
