918328-15-1Relevant articles and documents
PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS
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, (2018/12/13)
The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
Discovery of Highly Potent Liver X Receptor β Agonists
Kick, Ellen K.,Busch, Brett B.,Martin, Richard,Stevens, William C.,Bollu, Venkataiah,Xie, Yinong,Boren, Brant C.,Nyman, Michael C.,Nanao, Max H.,Nguyen, Lam,Plonowski, Artur,Schulman, Ira G.,Yan, Grace,Zhang, Huiping,Hou, Xiaoping,Valente, Meriah N.,Narayanan, Rangaraj,Behnia, Kamelia,Rodrigues, A. David,Brock, Barry,Smalley, James,Cantor, Glenn H.,Lupisella, John,Sleph, Paul,Grimm, Denise,Ostrowski, Jacek,Wexler, Ruth R.,Kirchgessner, Todd,Mohan, Raju
supporting information, p. 1207 - 1212 (2016/12/18)
Introducing a uniquely substituted phenyl sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. The ag
LIVER X RECEPTOR (LXR) MODULATORS
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Page/Page column 111, (2015/03/28)
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
