918350-11-5

Basic information

• Product Name: Benzaldehyde, 4-bromo-2-(methylthio)-
• Synonyms: Benzaldehyde,4-bromo-2-(methylthio);4-bromo-2-(methylthio)benzaldehyde;4-bromo-2-(methylsulfanyl)benzaldehyde
• CAS NO: 918350-11-5
• Molecular Formula: C8H7BrOS
• Molecular Weight: 231.113
• Mol File: 918350-11-5.mol

Chemical Properties

• Boiling Point: 301.3±37.0 °C(Predicted)
• Density: 1.57±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzaldehyde, 4-bromo-2-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-bromo-2-(methylthio)-(918350-11-5)
• EPA Substance Registry System: Benzaldehyde, 4-bromo-2-(methylthio)-(918350-11-5)

Safety Data

• Hazardous Substances Data: 918350-11-5(Hazardous Substances Data)

Upstream product

• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 126334-26-7 1-(4-bromophenyl)nonan-1-one 
• 918328-15-1 [4-bromo-2-(methylsulfanyl)phenyl]methanol 

Relevant articles and documents

Rhodium(III)-Catalyzed Aldehyde C?H Activation and Functionalization with Dioxazolones: An Entry to Imide Synthesis

A rhodium(III)-based catalytic system has been used to develop a C?H bond activation of benzaldehyde derivatives and subsequent functionalization with dioxazolones in order to afford imides. The importance of the nature of the directing group to perform selectively the aldehydic C?H bond activation has been highlighted. The scope investigation showed that this transformation could be applied to various dioxazolones and many benzaldehyde derivatives as well as an acrolein derivative. Derivatization reactions of the imide products demonstrated the synthetic utility of this rhodium-catalyzed aldehydic C?H amidation.

A rhodium-catalysed Sonogashira-type coupling exploiting C-S functionalisation: Orthogonality with palladium-catalysed variants

This report concerns the development of an efficient Sonogashira-type coupling of arylmethylsulfides and terminal alkynes to generate aryl alkyne motifs. Orthogonal reactivity between traditional Pd catalysts, and the Rh catalysts employed, results in the ability to selectively activate either the C-S bond or C-X bond through catalyst choice. The Rh-bisphosphine catalyst has further been shown to be able to effect a hydroacylation-Sonogashira tandem sequence, and in combination with further onward reactions has been used in the synthesis of heterocycles and polycyclic systems.

ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME

The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans a

Synthesis of 1,6-, 2,7-, 3,8-, and 4,9-isomers of didodecyl[1] benzothieno[3,2-b][1]benzothiophenes

The synthesis of 1,6-, 2,7-, 3,8-, and 4,9-isomers of dibromo- and didodecyl[1]benzothieno[3,2-b][1]benzothiophenes, via the stilbene pathway, is described. Starting from the synthesis of bromo-2-(methylthio)benzaldehydes, a series of functionalization, McMurry coupling, and finalising cyclization reactions were explored. The stereochemistry of the cyclization mechanism was investigated. Using this methodology didodecyl[1]benzothieno[3,2-b][1] benzothiophenes were formed in overall yields of 5-32%.