918411-71-9

Basic information

• Product Name: 7-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 7-[[(1S,2S,4R)-7-[(1,1-dimethylethoxy)carbonyl]-7-azabicyclo[2.2.1]hept -2-yl]carbonyl]-, phenylmethyl ester, (1S,2S,4R)-
• CAS NO: 918411-71-9
• Molecular Formula: C26H34N2O5
• Molecular Weight: 454.566
• Mol File: 918411-71-9.mol

Chemical Properties

• CAS DataBase Reference: 7-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 7-[[(1S,2S,4R)-7-[(1,1-dimethylethoxy)carbonyl]-7-azabicyclo[2.2.1]hept -2-yl]carbonyl]-, phenylmethyl ester, (1S,2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 7-[[(1S,2S,4R)-7-[(1,1-dimethylethoxy)carbonyl]-7-azabicyclo[2.2.1]hept -2-yl]carbonyl]-, phenylmethyl ester, (1S,2S,4R)-(918411-71-9)
• EPA Substance Registry System: 7-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 7-[[(1S,2S,4R)-7-[(1,1-dimethylethoxy)carbonyl]-7-azabicyclo[2.2.1]hept -2-yl]carbonyl]-, phenylmethyl ester, (1S,2S,4R)-(918411-71-9)

Safety Data

• Hazardous Substances Data: 918411-71-9(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 918411-42-4 (1S,2S,4R)-2-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester 
• 918411-52-6 (1S,2S,4R)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid benzyl ester 
• 1221818-81-0 endo-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid 
• 918411-46-8 (1S,2S,4R)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid 
• 197080-73-2 (+/-)-methyl endo-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane-2-carboxylate 

Relevant articles and documents

Oligomers of β-amino acid bearing non-planar amides form ordered structures

In this report, we explore the feasibility of using bicyclic chiral β-amino acids, (1R,2R,4S)- and (1S,2S,4R)-7-azabicyclo[2.2.1]heptane-2-carboxylic acid (R-Ah2c and S-Ah2c, respectively), to prepare novel peptides with unique properties. Facile cis-trans isomerization of the non-planar amide bonds of these β-amino acids should result in great flexibility of the backbone structure of β-peptides containing them. Indeed, oligomers of these amino acids showed thermostability and characteristic CD absorptions, which were not concentration-dependent, suggesting that the oligomers remained monomeric. The results indicated the formation of self-organized monomeric structures with chain-length-dependent stabilization. Energy calculations suggested that the peptides can take helical structures in which the energy barriers to cis-trans isomerization are greater for the central amide bonds than for the terminal amides.