918423-39-9

Basic information

• Product Name: Piperidine, 4,5-dimethyl-4-[3-(phenylmethoxy)phenyl]-2-(2-propen-1-yl)-, (2R,4R,5R)-
• CAS NO: 918423-39-9
• Molecular Formula: C23H29NO
• Molecular Weight: 335.489
• Mol File: 918423-39-9.mol

Chemical Properties

• CAS DataBase Reference: Piperidine, 4,5-dimethyl-4-[3-(phenylmethoxy)phenyl]-2-(2-propen-1-yl)-, (2R,4R,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 4,5-dimethyl-4-[3-(phenylmethoxy)phenyl]-2-(2-propen-1-yl)-, (2R,4R,5R)-(918423-39-9)
• EPA Substance Registry System: Piperidine, 4,5-dimethyl-4-[3-(phenylmethoxy)phenyl]-2-(2-propen-1-yl)-, (2R,4R,5R)-(918423-39-9)

Safety Data

• Hazardous Substances Data: 918423-39-9(Hazardous Substances Data)

Upstream product

• 205999-81-1 (+)-(3R,4R)-4-(3-(benzyloxy)phenyl)-3,4-dimethylpiperidine 
• 918423-37-7 (2R,4R,5R)-2-allyl-4-(3-benzyloxy-phenyl)-4,5-dimethyl-piperidin-1-ol 

Downstream Products

• 918423-53-7 1-((2R,4R,5R)-2-allyl-4-(3-benzyloxy-phenyl)-4,5-dimethyl-piperidin-1-yl)prop-2-en-1-one 

Relevant articles and documents

Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of μ-opioid receptor antagonists

The series of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines have been widely investigated as opioid receptor antagonists. One of our research goals was to explore the bioactive conformation of the N-phenethyl trans-3,4-dimethyl-4-(3-hydroxyphenyl)pipe

Synthesis and structure-activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists

Structure-activity relationships at the 2α-position of the piperidine ring of the trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine μ-opioid antagonist series were investigated. This study showed that only small linear alkyl groups (methyl, propyl) are tol