918423-53-7Relevant articles and documents
Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of μ-opioid receptor antagonists
Le Bourdonnec, Bertrand,Goodman, Allan J.,Michaut, Mathieu,Ye, Hai-Fen,Graczyk, Thomas M.,Belanger, Serge,Herbertz, Torsten,Yap, Glenn P. A.,DeHaven, Robert N.,Dolle, Roland E.
, p. 7278 - 7289 (2007/10/03)
The series of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines have been widely investigated as opioid receptor antagonists. One of our research goals was to explore the bioactive conformation of the N-phenethyl trans-3,4-dimethyl-4-(3-hydroxyphenyl)pipe