918423-40-2

Upstream product

• 918423-38-8 (2S,4R,5R)-2-allyl-4-(3-benzyloxy-phenyl)-4,5-dimethyl-piperidin-1-ol 
• 205999-81-1 (+)-(3R,4R)-4-(3-(benzyloxy)phenyl)-3,4-dimethylpiperidine 

Downstream Products

• 918423-42-4 1-((2S,4R,5R)-2-allyl-4-(3-(benzyloxy)phenyl)-4,5-dimethyl-piperidin-1-yl)-2-phenylethane-1,2-dione 
• 918423-54-8 1-((2S,4R,5R)-2-allyl-4-(3-benzyloxy-phenyl)-4,5-dimethyl-piperidin-1-yl)prop-2-en-1-one 
• 918423-44-6 1-((2S,4R,5R)-2-allyl-4-(3-(benzyloxy)phenyl)-4,5-dimethyl-piperidin-1-yl)-2-phenylprop-2-en-1-one 
• 918423-46-8 (7R,8R,9aS)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-3-phenyl-7,8,9,9a-tetrahydro-1H-quinolizin-4(6H)-one 
• 918423-50-4 (3R,7R,8R,9aS)-8-(3-hydroxyphenyl)-7,8-dimethyl-3-phenyl-hexahydro-1H-quinolizin-4(6H)-one 
• 918423-49-1 (3S,7R,8R,9aS)-8-(3-hydroxyphenyl)-7,8-dimethyl-3-phenyl-hexahydro-1H-quinolizin-4(6H)-one 
• 918423-56-0 (7R,8R,9aS)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-7,8,9,9a-tetrahydro-1H-quinolizin-4(6H)-one 
• 918423-58-2 (7R,8R,9aS)-8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-quinolizin-4(6H)-one 

Relevant academic research and scientific papers

NOVEL OPIOID ANTAGONISTS

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of μ-opioid receptor antagonists

The series of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines have been widely investigated as opioid receptor antagonists. One of our research goals was to explore the bioactive conformation of the N-phenethyl trans-3,4-dimethyl-4-(3-hydroxyphenyl)pipe