91846-80-9

Basic information

• Product Name: 1,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyridazine
• Synonyms: 1,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyridazine;1,4-dichloro-5H,6H,7H-cyclopenta[d]pyridazine;5H-Cyclopenta[d]pyridazine, 1,4-dichloro-6,7-dihydro-
• CAS NO: 91846-80-9
• Molecular Formula: C₇H₆Cl₂N₂
• Molecular Weight: 189
• Mol File: 91846-80-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 79-80℃
• Boiling Point: 367.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.466
• Storage Temp.: 2-8°C
• PKA: 0.23±0.20(Predicted)
• CAS DataBase Reference: 1,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyridazine(91846-80-9)
• EPA Substance Registry System: 1,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyridazine(91846-80-9)

Safety Data

• Hazardous Substances Data: 91846-80-9(Hazardous Substances Data)

Usage

General Description

1,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyridazine, also known as CP-465022, is a synthetic chemical compound that has been studied for its potential use in the treatment of neurological disorders and cognitive impairment. It is a potent and selective antagonist of the alpha-2 delta subunit of voltage-gated calcium channels, which are implicated in the transmission of pain signals in the central nervous system. Research has shown that CP-465022 has promising analgesic and anticonvulsant properties, making it a potential candidate for the development of new medications for conditions such as neuropathic pain and epilepsy. However, further research is needed to fully understand its safety and efficacy for clinical use.

Upstream product

• 106131-61-7 3,6-dichloro-1,2,4,5-tetrazine 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 13368-79-1 dimethylcyclopentene-1,2-dicarboxylate 
• 3128-15-2 cyclopent-1-ene-1,2-dicarboxylic acid 
• 92224-44-7 2,3,6,7-tetrahydro-1H-cyclopenta[d]pyridazine-1,4(5H)-dione 

Downstream Products

• 1204976-80-6 1-benzyl-4-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyridazine 
• 1204978-06-2 1-benzyl-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyridazine 

Relevant articles and documents

THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF

Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.

PYRIDAZINE DERIVATIVES AS HEDGEHOG PATHWAY INHIBITORS

This invention relates to novel compounds. The compounds of the invention are hedgehog pathway agonists. Specifically, the compounds of the invention are useful as Smoothened (SMO) agonists. The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of the Hedgehog pathway and SMO, for example cancer.

TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS

The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The i