918487-39-5

Upstream product

• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 811842-30-5 2-bromo-1-fluoro-4-iodobenzene 
• 1035265-80-5 ((3-bromo-4-fluorophenyl)ethynyl)trimethylsilane 

Downstream Products

• 1035265-81-6 5-[(3-bromo-4-fluorophenyl)ethynyI]-2-methoxyphenyl acetate 
• 1062292-60-7 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one 
• 1415142-14-1 4-(3-bromo-4-fluorobenzyl)-7-fluorophthalazin-1(2H)-one 
• 918483-79-1 4-(3-bromo-4-fluorophenylethynyl)-1-isopropyl-1H-pyrazole 

Relevant academic research and scientific papers

Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

PHTHALAZINE DERIVATIVES AS INHIBITORS OF PARP1, PARP2 AND/OR TUBULIN USEFUL FOR THE TREATMENT OF CANCER

The application relates to phthalazine derivatives of formula (I) which are inhibitors of PARP1, PARP2 and/or tubulin and thus useful for the treatment of cancer. Also disclosed are pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES

This invention relates to novel compounds having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.