918487-39-5

Basic information

• Product Name: 2-bromo-4-ethynyl-1-fluorobenzene
• Synonyms: 2-bromo-4-ethynyl-1-fluorobenzene
• CAS NO: 918487-39-5
• Molecular Weight: 199.022
• Mol File: 918487-39-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 202.9±30.0 °C(Predicted)
• Density: 1.58±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-bromo-4-ethynyl-1-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-ethynyl-1-fluorobenzene(918487-39-5)
• EPA Substance Registry System: 2-bromo-4-ethynyl-1-fluorobenzene(918487-39-5)

Safety Data

• Hazardous Substances Data: 918487-39-5(Hazardous Substances Data)

Upstream product

• 1035265-80-5 ((3-bromo-4-fluorophenyl)ethynyl)trimethylsilane 
• 811842-30-5 2-bromo-1-fluoro-4-iodobenzene 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 

Downstream Products

• 1035265-81-6 5-[(3-bromo-4-fluorophenyl)ethynyI]-2-methoxyphenyl acetate 
• 918483-79-1 4-(3-bromo-4-fluorophenylethynyl)-1-isopropyl-1H-pyrazole 
• 1415142-14-1 4-(3-bromo-4-fluorobenzyl)-7-fluorophthalazin-1(2H)-one 
• 1062292-60-7 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one 

Relevant articles and documents

Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES

This invention relates to novel compounds having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.