91850-97-4

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 100-46-9 benzylamine 

Downstream Products

• 123500-19-6 2-benzoyl-4,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-2-carboxylate 
• 1123339-19-4 (E)-N-cyclohexyl-2-[N-benzyl-N-(2-hydroxybenzoyl)amino]-3-hydroxy-3-phenylacrylamide 
• 1123339-18-3 (E)-N-cyclohexyl-2-[N-benzyl-N-benzoylamino]-3-hydroxy-3-phenylacrylamide 
• 1123338-93-1 (E)-N-cyclohexyl-2-[N-benzyl-N-(2-azidobenzoyl)amino]-3-hydroxy-3-phenylacrylamide 
• 1123339-20-7 (E)-N-cyclohexyl-2-[N-benzyl-N-(2-iodobenzoyl)amino]-3-hydroxy-3-phenylacrylamide 
• 51096-49-2 2-benzylamino-1-phenyl-ethanol 

Relevant academic research and scientific papers

A new entry to azomethine ylides from allylic amines and glyoxals: Shifting the reliance on amino ester precursors

The first examples of azomethine ylides derived from allylic amine and glyoxal precursors are reported. The condensation of primary allylic and α-aryl amines with glyoxylates or α-aryl glyoxals affords conjugated azomethine ylides that undergo facile [3 +

Synthesis of benzodiazepine β-turn mimetics by an Ugi 4CC/Staudinger/aza-wittig sequence. Solving the conformational behavior of the Ugi 4CC adducts

5-Oxobenzo[e][l,4]diazepine-3-carboxamides were synthesized by sequential Ugi reaction-Staudinger/aza-Wittig cyclization. The pseudopeptidic backbone of the new benzodiazepine derivatives superimposed well with type I, I, II, and II β-turn motifs. The intermediate Ugi adducts were characterized as two conformers of the enol form by the correlation between 1H NMR spectra and X-ray diffraction structures of model compounds.

The Reaction of Phenylglyoxal with Primary Aliphatic and Aromatic Amines. Synthesis of Phenylglyoxal Monoimines and some Derivatives.

Condensation of phenylglyoxal with primary aliphatic amines yields the related keto-aldimines.When primary aromatic amines are used, aldimines, amino-hydroxy-ketones, diamino-ketones, and alkoxy-amino-ketones are obtained depending upon the nature of the amine and the experimental conditions.Alternatively the monoimines can be obtained by dehydration of C-hydroxyphenacylarylamines and by demethanolation of C-methoxyphenacylarylamines both on treatment with Pd/C catalyst.Reduction of phenylglyoxal monoimines with sodium borohydride yielded H-substituted 1-phenyl-2-aminoethanols and 1,3-dipolar cycloaddition of the imines with p-chlorobenzonitrile oxide afforded 4-substituted 5-benzoyl-3-(p-chlorophenyl)-4,5-dihydro-1,2,4-oxadiazoles.