1123339-18-3Relevant academic research and scientific papers
Synthesis of benzodiazepine β-turn mimetics by an Ugi 4CC/Staudinger/aza-wittig sequence. Solving the conformational behavior of the Ugi 4CC adducts
Sanudo, Maria,Garcia-Valverde, Maria,Marcaccini, Stefano,Delgado, Jacinto J.,Rojo, Josefa,Torroba, Tomas
supporting information; experimental part, p. 2189 - 2192 (2009/08/07)
5-Oxobenzo[e][l,4]diazepine-3-carboxamides were synthesized by sequential Ugi reaction-Staudinger/aza-Wittig cyclization. The pseudopeptidic backbone of the new benzodiazepine derivatives superimposed well with type I, I, II, and II β-turn motifs. The intermediate Ugi adducts were characterized as two conformers of the enol form by the correlation between 1H NMR spectra and X-ray diffraction structures of model compounds.
