918633-70-2

Usage

Uses

Used in Chemical Research:
2-Bromoethyl-d4-amine HBr is used as a research compound for studying chemical reactions and processes. The incorporation of deuterium allows for the investigation of reaction mechanisms, kinetics, and the behavior of molecules in different environments.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-Bromoethyl-d4-amine HBr serves as a valuable tool for the development of new drugs and the understanding of drug metabolism. Its isotopically labeled nature enables researchers to track the compound's distribution, metabolism, and excretion within biological systems, which is crucial for assessing drug safety and efficacy.
Used in Analytical Chemistry:
2-Bromoethyl-d4-amine HBr is employed as a reference material in analytical chemistry for the calibration of instruments and the development of new analytical methods. The stable isotope labeling provides a means to differentiate the compound from its non-labeled counterparts, enhancing the accuracy and reliability of measurements.
Used in Environmental Studies:
This isotopically labeled compound is also utilized in environmental research to trace the fate and transport of chemicals in ecosystems. By monitoring the distribution and behavior of 2-Bromoethyl-d4-amine HBr, scientists can gain insights into the environmental impact of similar compounds and develop strategies for pollution control and remediation.

Upstream product

• 85047-08-1 2-amino(²H₄)ethan-1-ol 

Relevant academic research and scientific papers

Linking CO2 Sorption Performance to Polymer Morphology in Aminopolymer/Silica Composites through Neutron Scattering

Composites of poly(ethylenimine) (PEI) and mesoporous silica are effective, reversible adsorbents for CO2, both from flue gas and in direct air-capture applications. The morphology of the PEI within the silica can strongly impact the overall carbon capture efficiency and rate of saturation. Here, we directly probe the spatial distribution of the supported polymer through small-angle neutron scattering (SANS). Combined with textural characterization from physisorption analysis, the data indicate that PEI first forms a thin conformal coating on the pore walls, but all additional polymer aggregates into plug(s) that grow along the pore axis. This model is consistent with observed trends in amine-efficiency (CO2/N binding ratio) and pore size distributions, and points to a trade-off between achieving high chemical accessibility of the amine binding sites, which are inaccessible when they strongly interact with the silica, and high accessibility for mass transport, which can be hampered by diffusion through PEI plugs. We illustrate this design principle by demonstrating higher CO2 capacity and uptake rate for PEI supported in a hydrophobically modified silica, which exhibits repulsive interactions with the PEI, freeing up binding sites.

Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects

Evofosfamide (TH-302) is a clinical-stage hypoxia-activated prodrug with proven efficacy against hypoxic cells in preclinical tumour models. TH-302 is designed to release the DNA crosslinking agent bromo-isophosphoramide mustard (Br-IPM) when reduced in h

PHOSPHORAMIDATE ALKYLATOR PRODRUGS

Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.