85047-08-1

Hazards Identification

Pictogram(s):

Signal:

Danger

GHS Hazard Statements:

H302: Harmful if swallowed [Warning Acute toxicity, oral]
H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statement Codes:

P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501

Hazard Classes and Categories:

Acute Tox. 4 *
Skin Corr. 1B
Acute Tox. 4 (99.98%)
Skin Corr. 1B (99.96%)
Eye Dam. 1 (11.58%)
Acute Tox. 4 (99.73%)
STOT SE 3 (18.89%)
Aquatic Chronic 3 (12.2%)
Flam. Sol. 1 (100%)
Skin Sens. 1 (100%)
Aquatic Chronic 3 (100%)
Acute Tox. 4 (100%)
Skin Corr. 1B (100%)
Acute toxicity - category 4
Skin corrosion - category 1B
Flammable liquids - Category 4
Acute toxicity (Dermal) - Category 4
Skin corrosion/irritation - Category 1A
Serious eye damage/eye irritation - Category 1
Skin sensitization - Category 1
Specific target organ toxicity - Single exposure - Category 1 (central nervous system, respiratory system, liver), Category 3 (narcotic effects)
Specific target organ toxicity - Repeated exposure - Category 1 (central nervous system), Category 2 (respiratory system)
Acute toxicity (Oral) - Category 5
Acute toxicity (Dermal) - Category 3
Respiratory sensitization - Category 1
Reproductive toxicity - Category 2
Specific target organ toxicity - Single exposure - Category 1 (nervous system, liver)
Specific target organ toxicity - Repeated exposure - Category 1 (nervous system, testis, gastrointestinal tract, liver, kidney, respiratory system)
Hazardous to the aquatic environment (Acute) - Category 2
Corrosives, Flammable - 2nd degree

Hazards Summary:

Liquid causes first degree burns on short exposure; [CHRIS] Ethanolamine is a skin irritant. [Quick CPC] Occupational asthma reported in hairdressers; [Malo] Toxic to the liver in subchronic inhalation studies of animals; [ACGIH] It is an irritant, but allergic contact dermatitis has been reported. [Kanerva, p. 1817] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; Can cause skin sensitization; [ICSC] Danger of skin sensitization; [MAK]

Usage

Uses

Used in Organic Synthesis:
ETHANOL-1,1,2,2-D4-AMINE is used as a solvent or intermediate in organic synthesis for its unique properties that facilitate specific chemical reactions. The presence of deuterium atoms enhances its reactivity and stability, making it suitable for a range of applications in the synthesis of complex organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, ETHANOL-1,1,2,2-D4-AMINE is used as a key component in the development of new drugs. Its ability to form salts with acids can be leveraged to improve the solubility and bioavailability of certain pharmaceutical compounds, potentially leading to more effective treatments.
Used in Specialty Chemicals:
ETHANOL-1,1,2,2-D4-AMINE is employed in the production of specialty chemicals due to its distinctive properties. The deuterated form of ethanolamine can be integrated into the synthesis of high-performance materials, such as polymers and coatings, where its enhanced stability and reactivity contribute to improved product performance.
Used in Chemical Reactions:
ETHANOL-1,1,2,2-D4-AMINE is utilized in various chemical reactions for its capacity to react with acids and form salts. This characteristic makes it a valuable agent in processes that require the formation of specific salts or the alteration of the chemical properties of other compounds.

Upstream product

• 946524-40-9 N-(2-hydroxyethyl-1,1,2,2-⁽²⁾H₄)-5Z,8Z,11Z,14Z-eicosatetraenamide 
• 4896-75-7 <2-2H2>glycine 

Downstream Products

• 946524-43-2 4,7,10,13,16,19-docosahexaenoyl ethanolamide-d4 
• 1542204-48-7 2-((1,2-[²H₄]-2-hydroxyethyl)amino)-1-ethyl-7-(4-methoxybenzyl)-1H-purin-6(7H)-one 
• 1442117-44-3 Benzyl N-(2-hydroxy[²H₄]ethyl)carbamate 
• 1169692-38-9 2-aminoethyl dihydrogen phosphate-1,1,2,2-d4 
• 946524-40-9 N-(2-hydroxyethyl-1,1,2,2-⁽²⁾H₄)-5Z,8Z,11Z,14Z-eicosatetraenamide 
• 946524-41-0 5,8,11,14,17-eicosapentaenoyl ethanolamide-d4 
• 946524-34-1 palmitoyl ethanolamide-d4 
• 946524-36-3 oleoyl ethanolamide-d4 
• 918633-70-2 2-bromoethyl-1,1,2,2,-d₄-amine hydrobromide 

Relevant academic research and scientific papers

Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity

Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the hydrolysis of the endocannabinoid anandamide (arachidonoyl ethanolamide, AEA) to arachidonic acid (AA) and ethanolamine (EA). Published FAAH activity assays mostly employ radiolabeled anandamide or synthetic fluorogenic substrates. We report a stable isotope liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for specific, sensitive, and high-throughput capable FAAH activity measurements. The assay uses AEA labeled with deuterium on the EA moiety (d4-AEA) as substrate and measures the specific reaction product tetradeutero-EA (d4-EA) and the internal standard 13C2-EA. Selected reaction monitoring of m/z 66 → m/z 48 (d4-EA) and m/z 64 → m/z 46 (13C2-EA) in the positive electrospray ionization mode after liquid chromatographic separation on a HILIC (hydrophilic interaction liquid chromatography) column is performed. The assay was developed and thoroughly validated using recombinant human FAAH (rhFAAH) and then was applied to human blood and dog liver samples. rhFAAH-catalyzed d4-AEA hydrolysis obeyed Michaelis-Menten kinetics (KM = 12.3 μM, Vmax = 27.6 nmol/min mg). Oleoyl oxazolopyridine (oloxa) was a potent, partial noncompetitive inhibitor of rhFAAH (IC50 = 24.3 nM). Substrate specificity of other fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton. In human whole blood, we detected FAAH activity that was inhibited by oloxa.

Improved CILAT reagents for quantitative proteomics

Improved CILAT reagents have been developed, with which an unprecedented number of protein samples can be measured in high-throughput assays, providing a robust tool for MS-based quantitative proteomics.