918648-48-3

Upstream product

• 6940-78-9 4-chlorobutyl bromide 
• 170646-96-5 N-methoxy-N-methyl-3-phenylpropionamide 
• 104-53-0 3-phenyl-propionaldehyde 

Downstream Products

• 1032445-84-3 C₂₃H₃₆N₂O 
• 1032445-86-5 C₂₅H₃₂N₂O 
• 1441640-24-9 7-azido-1-phenylheptan-3-one 
• 26209-66-5 N-β-phenethylvalerolactam 
• 151647-54-0 3-phenyl-1-pyrrolidin-1-yl-propane-1-one 
• 1032469-82-1 C₁₆H₂₅NO 

Relevant academic research and scientific papers

Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction

A method for carrying out the intramolecular Schmidt reaction of alkyl azides and ketones using a substoichiometric amount of catalyst is reported. Following extensive screening, the use of the strong hydrogen-bond-donating solvent hexafluoro-2-propanol was found to be consistent with low catalyst loadings, which ranged from 2.5 mol % for favorable substrates to 25 mol % for more difficult cases. Reaction optimization, broad substrate scope, and preliminary mechanistic studies of this improved version of the reaction are described.

ANTIBACTERIAL QUINOLINE DERIVATIVES

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.

ANTIBACTERIAL QUINOLINE DERIVATIVES

The present invention relates to novel subst ituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or composit ions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.