918803-79-9Relevant academic research and scientific papers
Synthesis of the core ring system of awajanomycin from N-Boc-3-methoxycarbonyl-2-pyridinone
Hiroya, Kou,Kawamoto, Kei,Inamoto, Kiyofumi,Sakamoto, Takao,Doi, Takayuki
, p. 2115 - 2118 (2009)
Awajanomycin, which was isolated from marine-derived fungus, possesses unique structural features and cytotoxic activity against A549 cells. Due to its unique structure, no total synthesis has yet been reported, and neither the relative stereochemistry no
Introduction of the acetate unit to the 2-pyridinone ring system and its application to the synthesis of (20S)-camptothecin DE ring system
Hiroya, Kou,Kawamoto, Kei,Sakamoto, Takao
, p. 2636 - 2640 (2008/09/16)
The DE ring system of (20S)-camptothecin had been prepared from commercially available nicotinic acid in six steps utilizing the nucleophilic addition reaction of the silyl ketene acetal to the pyridinone ring as a key step. Georg Thieme Verlag Stuttgart.
