918803-80-2Relevant academic research and scientific papers
Introduction of the acetate unit to the 2-pyridinone ring system and its application to the synthesis of (20S)-camptothecin DE ring system
Hiroya, Kou,Kawamoto, Kei,Sakamoto, Takao
, p. 2636 - 2640 (2006)
The DE ring system of (20S)-camptothecin had been prepared from commercially available nicotinic acid in six steps utilizing the nucleophilic addition reaction of the silyl ketene acetal to the pyridinone ring as a key step. Georg Thieme Verlag Stuttgart.
Synthesis of the core ring system of awajanomycin from N-Boc-3-methoxycarbonyl-2-pyridinone
Hiroya, Kou,Kawamoto, Kei,Inamoto, Kiyofumi,Sakamoto, Takao,Doi, Takayuki
scheme or table, p. 2115 - 2118 (2009/07/19)
Awajanomycin, which was isolated from marine-derived fungus, possesses unique structural features and cytotoxic activity against A549 cells. Due to its unique structure, no total synthesis has yet been reported, and neither the relative stereochemistry no
