918829-84-2

Upstream product

• 918829-62-6 tert-butyl (3R,4R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-3,4-dimethylpiperidine-1-carboxylate 
• 918829-63-7 (2R,4R,5R)-1-(tert-butoxycarbonyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-2-carboxylic acid 
• 918829-75-1 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-(2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 205999-74-2 4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-tert-butyloxycarbonylpiperidine 

Downstream Products

• 918829-92-2 (7R,8R,9aR)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-2-(phenylsulfonyl)-octahydro-1H-pyrido[1,2-a]pyrazine 
• 918829-90-0 tert-butyl (7R,8R,9aR)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate 
• 918829-22-8 1-((7R,8R,9αR)-8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2-α]pyrazin-2(6H)-yl)-3-phenylpropan-1-one 
• 918829-91-1 (7R,8R,9aR)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-2-phenyl-octahydro-1H-pyrido[1,2-a]pyrazine 
• 918829-21-7 1-((7R,8R,9αR)-8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2-α]pyrazin-2(6H)-yl)-2-phenylethanone 

Relevant academic research and scientific papers

NOVEL OPIOID ANTAGONISTS

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2- a]pyrazine as μ-opioid receptor antagonists

To better understand structural requirements for a μ ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)-piperidine class to interact with the μ opioid receptor, we have described in the previous article (Le Bourdonnec, B. et al. J. Med. Chem. 2006, 25,