205999-74-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 119193-19-0 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol 

Downstream Products

• 762299-36-5 3(R),4-dimethyl-4(R)-(3-trifluoromethanesulfonyloxyphenyl)-1-tert-butyloxycarbonylpiperidine 
• 205999-77-5 3-[(3R,4R)-4-(3-Benzyloxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-1-phenyl-cyclohexanol 
• 205999-81-1 (+)-(3R,4R)-4-(3-(benzyloxy)phenyl)-3,4-dimethylpiperidine 
• 918829-72-8 tert-butyl (2R,4R,5R)-2-(benzyl(3-ethoxy-3-oxopropyl)carbamoyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-78-4 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-cyclohexyl-1-methoxy-1-oxoethyl-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-77-3 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-76-2 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-1-oxo-3-phenylpropan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-68-2 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((R)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-64-8 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-79-5 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-3-methyl-1-oxobutan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-67-1 3-((3S,7R,8R,9aR)-2-benzyl-7,8-dimethyl-3-phenyl-octahydro-1H-pyrido[1,2-a]pyrazin-8-yl)phenyl trifluoromethanesulfonate 
• 918829-75-1 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-(2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-82-0 methyl 2-(S)-cyclohexyl-2-((2R,4R,5R)-4-(3-hydroxyphenyl)-4,5-dimethylpiperidine-2-carboxamido)-acetate 
• 918829-92-2 (7R,8R,9aR)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-2-(phenylsulfonyl)-octahydro-1H-pyrido[1,2-a]pyrazine 

Relevant academic research and scientific papers

NOVEL OPIOID ANTAGONISTS

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

Substituted piperidine compounds

Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, in

trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of μ-Selective opioid antagonists

trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines constitute a novel class of μ opioid receptor antagonists. The CONH2 group was found to be an effective isostere of the phenolic OH moiety. Structure-activity relationships at the piperidine

Investigation of the N-substituent conformation governing potency and μ receptor subtype-selectivity in (+)-(3R,4R)-dimethyl-4-(3- hydroxyphenyl)piperidine opioid antagonists

A study of the binding site requirements associated with the N- substituent of (+)-(3R,4R)dimethyl-4-(3-hydroxyphenyl)piperidine (4) derivatives was undertaken using a set of rigid vs flexible N-substituents. The study showed that compounds 7-9 bearing th