918896-35-2

Upstream product

• 918896-33-0 ethyl 3-(6-methoxy 7-methyl benzo[d][1,3]dioxol-5-yl)-(E)-2-propionate 
• 80592-18-3 3,4-methylenedioxyphenyl formate 
• 533-31-3 Sesamol 
• 120-57-0 piperonal 
• 111726-43-3 3,4-(methylenedioxy)phenyl methoxymethyl ether 
• 187040-02-4 5-methoxy methoxy-4-methyl benzo[d][1,3]dioxole 
• 187040-03-5 4-methylbenzo[1,3]dioxol-5-ol 
• 187040-23-9 6-methoxy 7-methyl benzo[d][1,3]dioxole-5-carbaldehyde 
• 607351-59-7 5-methoxy 4-methyl benzo[d][1,3]dioxole 

Relevant academic research and scientific papers

Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2-methyl anisole, and veratraldehyde. A combination of Vilsmeier-Haack reaction and Sharpless asymmetric dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed for the synthesis of building block C.