918896-53-4

Upstream product

• 578-58-5 2-methylmethoxybenzene 
• 209624-66-8 3-hydroxy-4-methoxy-5-methylbenzaldehyde 
• 32723-67-4 3-methyl-4-anisaldehyde 
• 918896-47-6 3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzaldehyde 
• 918896-43-2 2-(3-hydroxy-4-methoxy-5-methyl phenyl)-1,3-dioxolane 
• 918896-39-6 2-(3-bromo-4-methoxy-5-methyl phenyl)-1,3-dioxolane 
• 808750-22-3 3-bromo-4-methoxy-5-methyl benzaldehyde 
• 918896-50-1 ethyl 3-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-(E)-2-propionate 

Downstream Products

• 1026340-65-7 (4R,5S)-5-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-2-oxo-2λ⁴-[1,3,2]dioxathiolane-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2-methyl anisole, and veratraldehyde. A combination of Vilsmeier-Haack reaction and Sharpless asymmetric dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed for the synthesis of building block C.