918896-64-7

Basic information

• Product Name: 6-benzyloxy-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• Synonyms: 6-benzyloxy-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
• CAS NO: 918896-64-7
• Molecular Weight: 527.777
• Mol File: 918896-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-benzyloxy-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyloxy-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(918896-64-7)
• EPA Substance Registry System: 6-benzyloxy-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester(918896-64-7)

Safety Data

• Hazardous Substances Data: 918896-64-7(Hazardous Substances Data)

Upstream product

• 918896-63-6 6-benzyloxy-1-(2-hydroxy-ethyl)-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 918896-59-0 1-benzyloxy-4-bromo-2-methoxy-5-(2-nitro ethyl)benzene 
• 918896-60-3 2-[2-bromo-4-methoxy-5-benzyloxy]-1-(tert-butoxycarbonyl amino)-ethane 
• 1026439-42-8 (E)-3-[2-(2-Amino-ethyl)-4-benzyloxy-5-methoxy-phenyl]-acrylic acid ethyl ester 
• 1026556-60-4 (6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester 
• 918896-62-5 6-benzyloxy-1-ethoxycarbonylmethyl-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 918896-61-4 2-[2-(ethylpropionate)-4-methoxy-5-benzyloxy]-1-(tert-butoxycarbonyl-amino)-ethane 
• 2973-59-3 2-bromoisovanillin 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 6451-86-1 5-benzyloxy-2-bromo-4-methoxybenzaldehyde 
• 141035-23-6 5-Benzyloxy-2-brom-4-methoxy-phenaethylamin 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 918896-58-9 1-benzyloxy-4-bromo-2-methoxy-5-[2-nitro-(E)-1-ethenyl]benzene 

Relevant articles and documents

Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2-methyl anisole, and veratraldehyde. A combination of Vilsmeier-Haack reaction and Sharpless asymmetric dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed for the synthesis of building block C.